Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh

Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh

There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms. Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis. Both patients reported black cohosh...

Black Cohosh Hepatotoxicity with Autoimmune Hepatitis Presentation

Herbal medicines have been used for the treatment of various ailments since time immemorial. Black cohosh (BC) is well known for the treatment of postmenopausal symptoms, with conflicting evidence supporting its safety and benefits. We present a rare case of BC-induced autoimmune hepatitis (AIH) with hepatotoxicity in a 69-year-old female. To our knowledge, this represents the third case of BC-...

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury.

BACKGROUND & AIMS Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin, minocycline, methyldopa, or hydralazine. METHODS We analyzed data from 88 cases of DILI attributed to nitrofurantoin, minocycline, methyldopa, or hy...

Black cohosh and other herbal remedies associated with acute hepatitis.

Six patients presented with clinical, biochemical and histological evidence of severe hepatitis after taking herbal remedies. One patient required urgent liver transplantation for fulminant hepatic failure after the brief use of black cohosh. Five patients took a combination of herbs and presented with jaundice, fatigue and pruritus. Healthcare providers and members of the public should be awar...

Black Cohosh